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Investigations of patients with suspected NSCLC focus on confirming the diagnosis and determining the extent of the disease.

Treatment options for patients are determined by histology, stage, and general health and comorbidities of the patient.

Other genetic abnormalities of potential relevance to treatment decisions include translocations involving the anaplastic lymphoma kinase (ALK)-tyrosine kinase receptor, which are sensitive to ALK inhibitors, and amplification of For patients with inoperable disease, prognosis is adversely affected by poor performance status and weight loss of more than 10%.

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Malignant non-small cell epithelial tumors of the lung are classified by the World Health Organization (WHO)/International Association for the Study of Lung Cancer (IASLC).

There are three main subtypes of non-small cell lung cancer (NSCLC), including the following: Most squamous cell carcinomas of the lung are located centrally, in the larger bronchi of the lung.

Patients with locally advanced unresectable disease may achieve long-term survival with radiation therapy combined with chemotherapy.

Patients with advanced metastatic disease may achieve improved survival and palliation of symptoms with chemotherapy, targeted agents, and other supportive measures.

Infrequently, patients may present with symptoms and signs of paraneoplastic diseases such as hypertrophic osteoarthropathy with digital clubbing or hypercalcemia from parathyroid hormone-related protein.